Fig. 5.

The effect of acute (a) or chronic (b) administration of 1MeTIQ on 1BnTIQ-induced changes in 3-MT concentration in the rat striatum, 1BnTIQ was administered chronically (1BnTIQch) at a dose 25 mg/kg i.p. for 14 consecutive days. In the mixed group, 1MeTIQ (50 mg/kg i.p.) was given acutely (1MeTIQa) a 20 min before last 1BnTIQ administration or chronically (1MeTIQch), b 20 min before each 1BnTIQ administration. The control group was treated with saline. The dialysate was collected every 20 min. The concentration of extraneuronal metabolite of dopamine 3-MT was measured. The data are expressed as the mean ± SEM (n = 5–6). Statistical significance: *p < 0.05, **p < 0.01 from the basal value; ⁺ p < 0.05 versus 1BnTIQ-treated group (Duncan’s test)