Table 5.

Cost effectiveness analysis estimates for the missing data methods

	RA	CCA (% bias)	MI-PMM (% bias)	Log MI-PMM (% bias)	Two-step MI (% bias)
17 % Missing data
Correlation utility and costs	0.0507	0.0591	0.0517	0.0509	0.0487
Covariance	5.6	8.6	6.7	6.6	6.4
Mean (INB)	14,422	16,026 (11)	15,257 (6)	15,654 (9)	15,023 (4)
SE INB	6083	7270 (20)	6438 (6)	6457 (6)	6504 (7)
95 % CI lower limit	4417	4069	4669	5034	4324
95 % CI upper limit	24,427	27,983	25,846	26,274	25,721
Prob C-E	0.99	0.99 (0)	0.99 (0)	0.99 (0)	0.99 (0)
ICER	−235,472	−235,448 (0)	−220,988 (6)	−227,410 (3)	−217,656 (8)
35 % Missing data
Correlation utility and costs	0.0507	0.0251	0.0300	0.0292	0.028
Covariance	5.6	4.9	4.4	4.4	4.4
Mean (INB)	14,422	11,105 (23)	13,029 (10)	13,143 (9)	12,841 (11)
SE (INB)	6083	8685 (43)	6864 (13)	7000 (15)	6966 (15)
95 % CI lower limit	4417	−3181	1738	1629	1383
95 % CI upper limit	24,427	25,390	24,319	24,656	24,299
Prob C-E	0.99	0.90 (9)	0.97 (2)	0.97 (2)	0.97 (2)
ICER	−235,472	−134,488 (43)	−158,857 (33)	−156,289 (34)	−155,935 (34)
50 % Missing data
Correlation utility and costs	0.0507	0.0223	0.0433	0.0436	0.0406
Covariance	5.6	5.5	7.0	7.0	6.7
Mean (INB)	14,422	8786 (39)	12,682 (12)	12,867 (11)	11,907 (17)
SE (INB)	6083	9584 (58)	6858 (13)	6770 (11)	6962 (14)
95 % CI lower limit	4417	−6978	1401	1731	456
95 % CI upper limit	24,427	24,551	23,962	24,003	23,358
Prob C-E	0.99	0.82 (17)	0.97 (2)	0.97 (2)	0.96 (3)
ICER	−235,472	−155,561 (34)	−134,979 (43)	−144,317 (39)	−128,670 (45)

SE standard error, INB incremental net benefit (euros), CI confidence interval, Prob C-E probability of cost-effectiveness, ICER incremental cost effectiveness ratio