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. 2016 Sep 12;5(9):e258. doi: 10.1038/oncsis.2016.59

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ARHGEF5-dependent activation of Akt is required for tumor growth from mesenchymal-like colorectal cancer cells. (a) HCT116 cells were treated with TNF-α (50 ng/ml) for the indicated periods, and the levels of the indicated proteins analyzed by western blotting. (b) HT29, SW480 and SW620 cells were transfected with control shRNA or shGEF5 no. 1 and the levels of the indicated proteins were analyzed by western blotting. (c) SW480 and SW620 cells treated with dimethyl sulfoxide (DMSO) or with the indicated concentrations of Akt inhibitor were subjected to soft agar colony formation assays. Values represent the mean±s.d. (n=3, ***P<0.001).