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Effect of TQ loaded PLGA nanoparticles on glutathione level in the brain of MCAO rats. The intranasal delivery of TQ-PLGA nanoparticles led to significant elevation in the GSH levels in the MCAO rats when compared to TQ solution delivered by intranasal or oral route alone (N = 6; data represent mean ± SEM; ¶¶ P < 0.01 versus sham control; ∗∗ P < 0.01 versus MCAO control; and ∗ P < 0.05 versus MCAO control).
