Table 3.
Effect of thymoquinone loaded PLGA nanoparticles on the catalase and SOD activity in the brain of MCAO rats.
| Groups | Treatment | Catalase (n moles of H2O2/min/mg protein) |
SOD (U/mg protein) |
|---|---|---|---|
| 1 | Sham control | 3.81 ± 0.112 | 7.30 ± 0.031 |
| 2 | MCAO control | 1.54 ± 0.106¶¶ | 4.53 ± 0.311¶¶ |
| 3 | MCAO + TQ PLGA NPs (i.n.) | 3.64 ± 0.054∗ | 7.01 ± 0.078∗∗ |
| 4 | MCAO + TQ solution (i.n.) | 2.06 ± 0.018 | 5.57 ± 0.031∗ |
| 5 | MCAO + TQ solution (oral) | 1.96 ± 0.021 | 5.49 ± 0.084∗ |
The intranasal delivery of TQ-PLGA nanoparticles led to significant increase in the antioxidant enzymes catalase and SOD in the MCAO rats when compared to TQ solution delivered by intranasal or oral route alone. N = 6; data represent mean ± SEM; ¶¶ P < 0.01 versus sham control; ∗∗ P < 0.01 versus MCAO control; and ∗ P < 0.05 versus MCAO control.