Table 3.

HCP patients at 12-month post-surgery, cross-sectional comparisons of regional network measures with the Control Group. Regional network measures include nodal degree, betweenness centrality, clustering coefficient, and nodal efficiency. All regional network values are the area under curve over the network density range between 0.2 and 0.4 (at interval of 0.01) using residual value of network measure based on linear regression to account for age factor at each density level. All p values are FDR corrected across the four network measures and 31 nodes in the network to minimize false positive findings resulting from multiple comparisons. Only those nodes that showed significant group difference in one or more measures are included.

Region	Degree			Betweenness centrality			Clustering coefficient			Local efficiency
	CTL n = 34	12 m post-surgery n = 24	t (corrected p)	CTL n = 34	12 m post-surgery n = 24	t (corrected p)	CTL n = 34	12 m post-surgery n = 24	t (corrected p)	CTL n = 34	12 m post-surgery n = 24	t (corrected p)
	Mean ± std	Mean ± std		Mean ± std	Mean ± std		Mean ± std	Mean ± std		Mean ± std	Mean ± std
SPG	0.000 ± 0.825	0.632 ± 1.143	2.45 (0.0772)	0.000 ± 0.016	0.022 ± 0.039	3.00 (0.0313)	0.000 ± 0.024	0.001 ± 0.036	0.11 (ns)	0.000 ± 0.015	− 0.001 ± 0.023	− 0.16 (ns)
CingG	0.000 ± 0.376	0.961 ± 0.906	5.56 (< 0.0001)	0.000 ± 0.010	0.021 ± 0.023	4.79 (0.0004)	0.000 ± 0.019	0.009 ± 0.022	1.69 (ns)	0.000 ± 0.016	0.009 ± 0.016	2.17 (ns)
SFG	0.000 ± 0.927	− 0.902 ± 0.854	− 3.77 (0.0049)	0.000 ± 0.029	− 0.017 ± 0.027	− 2.34 (0.0946)	0.000 ± 0.015	0.023 ± 0.033	3.58 (0.0081)	0.000 ± 0.010	0.013 ± 0.022	2.94 (0.031)
MFG	0.000 ± 0.771	− 0.688 ± 1.008	− 2.95 (0.0323)	0.000 ± 0.009	− 0.002 ± 0.012	− 0.76 (ns)	0.000 ± 0.038	0.016 ± 0.041	1.56 (ns)	0.000 ± 0.020	0.006 ± 0.024	0.99 (ns)
MOG	0.000 ± 0.675	− 0.665 ± 1.109	− 2.84 (0.0358)	0.000 ± 0.022	− 0.019 ± 0.024	− 3.10 (0.0265)	0.000 ± 0.022	0.031 ± 0.034	4.21 (0.0023)	0.000 ± 0.014	0.018 ± 0.020	4.01 (0.004)
Amyg	0.000 ± 0.484	0.526 ± 0.540	3.89 (0.0037)	0.000 ± 0.004	0.002 ± 0.007	1.40 (ns)	0.000 ± 0.075	0.091 ± 0.103	3.90 (0.0040)	0.000 ± 0.085	0.098 ± 0.105	3.91 (0.004)
Hippo	0.000 ± 0.458	0.494 ± 0.849	2.86 (0.0351)	0.000 ± 0.014	0.005 ± 0.015	1.28 (ns)	0.000 ± 0.041	− 0.005 ± 0.055	− 0.41 (ns)	0.000 ± 0.040	− 0.006 ± 0.047	− 0.52 (ns)
Caud	0.000 ± 0.627	0.908 ± 1.581	3.04 (0.0300)	0.000 ± 0.004	0.010 ± 0.020	2.89 (0.0341)	0.000 ± 0.082	− 0.073 ± 0.076	− 3.44 (0.0115)	0.000 ± 0.080	− 0.055 ± 0.086	− 2.47 (0.076)
Put	0.000 ± 0.613	0.051 ± 1.089	0.23 (ns)	0.000 ± 0.008	0.010 ± 0.016	3.18 (0.0231)	0.000 ± 0.034	− 0.030 ± 0.059	− 2.42 (0.0802)	0.000 ± 0.033	− 0.032 ± 0.063	− 2.52 (0.070)
Thal	0.000 ± 0.758	− 1.741 ± 1.408	− 6.08 (< 0.0001)	0.000 ± 0.023	− 0.033 ± 0.024	− 5.21 (0.0001)	0.000 ± 0.024	0.023 ± 0.043	2.62 (0.0609)	0.000 ± 0.027	− 0.007 ± 0.045	− 0.73 (ns)