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. 2016 Oct 4;6:34695. doi: 10.1038/srep34695

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) The concentrations of AI-2 induced in the context of three types of spatial distributions of cells were quantified with a biological method. (b) A schematic of the AI-2 distribution. Most of the AI-2 was restricted in the cell aggregates, and the remainder diffused outside the microcapsules. Error bars represent the standard deviation of three replicates. Significant differences between groups were analyzed by t-test. Single asterisk indicates significant difference (p < 0.05) and double asterisk indicates significant difference (p < 0.01).