Table 1. Significantly altered metabolites in the serum samples of vehicle-, raw PR- and PRZA-treated rats.
| No. | tR (min) | Extract mass | Formula | Compound | Fold change | |
|---|---|---|---|---|---|---|
| Raw PR vs. Control | PRZA vs. Control | |||||
| 1 | 0.6906 | 115.0633 | C5H9NO2 | Proline | ↑/1.87 | ↑/1.83 |
| 2 | 1.3981 | 131.0946 | C6H13NO2 | Leucine | ↑/1.59 | — |
| 3 | 5.2621 | 208.0848 | C10H12N2O3 | Kynurenine | — | ↑/1.57 |
| 4 | 1.7704 | 176.0950 | C10H12N2O | 5-hydroxytryptamine (5-HT) | ↑/1.94 | — |
| 5 | 9.1083 | 114.0429 | C4H6N2O2 | Dihydrouracil | ↑/1.92 | ↑/1.94 |
| 6 | 9.5202 | 381.2644 | C18H40NO5P | Dihydrosphingosine 1-phosphate (dhS1P) | ↑/1.62 | ↑/1.66 |
| 7 | 10.8046 | 148.0190 | C5H8O3S | 2-keto-4-methylthiobutyric acid (KMTB) | ↑/1.44 | ↑/1.60 |
| 8 | 11.7082 | 276.1321 | C11H20N2O6 | Saccharopine | ↓/−1.76 | ↓/−1.98 |
| 9 | 0.6774 | 137.0477 | C7H7NO2 | P-aminobenzoate (PABA) | — | ↑/1.98 |
| 10 | 1.1796 | 181.0739 | C9H11NO3 | Tyrosine | — | ↑/1.81 |
↑up-regulation; ↓down-regulation; —: no significant change.