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. 2016 Sep 20;6(9):e896. doi: 10.1038/tp.2016.160

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Copyright © 2016 The Author(s)

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EET effects on BDNF protein levels in the hippocampus (left) and frontal cortex (right) measured by ELISA. (a) BDNF levels in WT and KIV mice after EET (SCT/EET, T₁), then after 1 month of SCT (SCT–SCT/EET–SCT, T₂). Asterisks on the columns show a significant difference between genotypes. Data are combined (N=8–10) from male (N=4–5) and female (N=4–5) mice because no gender differences were observed. (b) EET effects shown as % SCT across ages at T₁ (top) and at T₂ (bottom). Asterisks on the columns show a significant effect of EET compared to SCT. BDNF, brain-derived neurotrophic factor; ED, early-life development; EET, enriched environment treatment; KIV, knock-in BDNF-promoter IV; OA, old adult; SCT, standard condition treatment; WT, wild-type; YA, young adult. *P<0.05, **P<0.01, ***P<0.005.