Figure 1.

Bupropion responders vs non-responders GWAS. (a) Manhattan plot—the Manhattan plot depicts the distribution of association test statistics versus genomic position, with chromosomes 1 to 22, X, and Y arranged along the x axis. The y axis represents log-scaled P-values. Positions with P<5 × 10−8 (a score of about 7.3) are shown in red. Loci with smallest P<10−6 are labeled with the name of the nearest gene. A ‘good' Manhattan plot should show towers of single-nucleotide polymorphisms (SNPs) with small P-values supporting most signals that pass the genome-wide threshold. (b) Regional association plots—the regional association plots show association test statistics versus position in the vicinity of the strongest associations. The plots are generated with LocusZoom,²² using linkage disequilibrium data from the March 2012 release of 1000 Genomes data. In the plots, a ‘o' symbol indicates a genotyped SNP and a ‘+' indicates an imputed SNP. Color indicates strength of linkage disequilibrium with the index SNP. GWAS, genome-wide association study.