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. 2016 Sep 13;6(9):e890. doi: 10.1038/tp.2016.173

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Functional analysis of overlap between sets of genes enriched in SCZ (a) and BPD (b) in the hippocampus. Red circles denote gene sets with increased expression-affected individuals, whereas blue circles indicate decreased expression. The size of each circle represents the number of genes in each set, while the thickness of the lines connecting two circles represents the proportion of genes that are in common between the two gene sets. A fully labeled version of each figure is available in the Supplementary Information (Supplementary Figures S2 and S3). The major functional networks are as follows: (a1) messenger RNA (mRNA) processing and translation, transport of ribonucleoproteins, transmembrane transport, interferon signaling and cytokine signaling; (a2) respiration/oxidative phosphorylation and genes implicated in Parkinson's, Alzheimer's and Huntington's diseases; (a3) developmental biology, transcriptional regulation and axon guidance; (a4) defensins, innate immunity and complement cascade; (a5) neuronal systems and neural transmitter signaling; (a6) extracellular matrix proteins; (a7) endocytosis and intracellular trafficking; (b1) cell cycle regulation; (b2) Major histocompatibility (MHC) Class I antigen presentation, ubiquitin-mediated degradation by the proteasome and related signaling networks; (b3) mRNA processing and translation; (b4) protein folding and import into mitochondria; (b5) transcription termination, mRNA splicing and transport, interferon and cytokine signaling; (b6) neuronal signaling cascades; (b7) respiration/oxidative phosphorylation and genes implicated in Parkinson's, Alzheimer's and Huntington's diseases; (b8) phospholipid metabolism; (b9) fatty acid and keytone metabolism, and regulation of peroxisomes and adipocites; (b10) transfer RNA (tRNA) biosynthesis; (b11) RNA polymerase III regulation; (b12) biological oxidations and drug metabolism by cytochrome p450. BPD, bipolar disorder; SCZ, schizophrenia.