Table 1. Demographic information for samples included in gene expression analysis.
Group |
Hippocampus (cohort 1) |
Orbitofrontal cortex (replication cohort) |
|||||
---|---|---|---|---|---|---|---|
SCZ | BPD | Controls | SCZ | BPD | MDD | Controls | |
Number | 35 | 33 | 32 | 13 | 14 | 15 | 15 |
Age | 42.6 | 45.4C | 43.9 | 44.65 | 41.9 | 46.5 | 48.1 |
Age range | 19–59 | 19–64 | 31–60 | 25–62 | 25–61 | 30–65 | 29–68 |
Sex | 9F, 26M | 18F, 15M | 9F, 24M | 8M, 5F | 9M, 5F | 9M, 6F | 9M, 6F |
Race | 34C, 1H | 32C, 1NA | 32C | 10C, 3A | 13C, 1AA | 15C | 14C, 1AA |
PMI (h) | 31.4 | 38 | 30 | 35.8 | 30.9 | 27.5 | 23.7 |
PMI range | 9–80 | 12–84 | 9–58 | 12–61 | 13–62 | 7–47 | 8–42 |
pH | 6.5 | 6.4 | 6.6 | 6.2 | 6.2 | 6.2 | 6.3 |
pH range | 5.9–6.9 | 5.8–7 | 6–7 | 5.8–6.6 | 5.8–6.5 | 5.8–6.5 | 5.8–6.6 |
Side | 17L, 18R | 18L, 15R | 15L, 17R | 8L, 5R | 6L, 8R | 9L, 6R | 8L, 7R |
Mood stabilizers | 10Y, 24N | 21Y, 11N, 1NA | 32N | 3Y, 10N | 9Y, 5N | 2Y, 13N | 15N |
Antidepressants | 9Y, 25N | 19Y, 13N, 1NA | 32N | 5Y, 8N | 7Y, 7N | 127, 3N | 15N |
Antipsychotics | 35Y | 22Y, 11N | 32N | 12Y, 1N | 11Y, 3N | 15N | 15N |
Lifetime dosage | 85 004 | 9915 | 0 | 61 077 | 20 032 | 0 | 0 |
Dosage range | 50–400 000 | 0–130 000 | 0 | 0–150 000 | 0–60 000 | 0 | 0 |
Abbreviations: BPD, bipolar disorder; F, female; L, left; M, male; MDD, major depressive disorder; NA, not available; PMI, postmortem interval; R, right; SCZ, schizophrenia.
Information on matched traits for hippocampus samples (N=100 after removing outliers) from the Stanley Microarray Collection and OFC samples (N=57 after removing outliers) from the Stanley Neuropathology Consortium Collection that were included in the differential expression analysis. 'AA' represents African American, 'A' represents Asian, 'C' represents Caucasian, 'H' represents Hispanic. ‘Mood Stabilizers', ‘Antidepressants' and ‘Antipsychotics' are listed as 'Y' if there is a record of an individual having ever taken one and 'N' if there is no such record. ‘Lifetime dosage' is the mean estimated lifetime dosage of antipsychotics in fluphenazine equivalents (mg). ‘Dosage range' is the lowest and highest lifetime dosages of antipsychotics of all individuals in each group.