Table 2. Genes differentially expressed in the hippocampus in schizophrenia and bipolar disorder.
Gene | All |
Schizophrenia vs control |
Bipolar disorder vs control |
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---|---|---|---|---|---|---|---|---|---|---|---|
Counts | log2FC | lfcSE | Wald | P-value | MTC P | log2FC | lfcSE | Wald | P-value | MTC P | |
LOC100131257 | 219.38 | 0.41 | 0.08 | 5.43 | 5.52E−08 | 9.06E−04 | 0.1 | 0.07 | 1.38 | 1.69E−01 | 1 |
LOC100288637 | 309.86 | −0.38 | 0.08 | −4.94 | 7.80E−07 | 4.27E−03 | −0.31 | 0.08 | −4.06 | 4.92E−05 | 0.12 |
KIF19 | 1732.95 | 0.46 | 0.09 | 5.01 | 5.50E−07 | 4.27E−03 | 0.18 | 0.09 | 1.97 | 4.88E−02 | 1 |
SLC11A1 | 304.43 | 0.42 | 0.09 | 4.77 | 1.82E−06 | 7.48E−03 | 0 | 0.09 | 0.04 | 9.67E−01 | 1 |
FKBP5 | 2769.46 | 0.41 | 0.09 | 4.34 | 1.40E−05 | 3.29E−02 | 0.29 | 0.09 | 3.12 | 1.78E−03 | 0.88 |
GNA14 | 599.69 | 0.38 | 0.09 | 4.35 | 1.36E−05 | 3.29E−02 | 0.07 | 0.09 | 0.78 | 4.35E−01 | 1 |
LOC100188947 | 150.82 | 0.35 | 0.08 | 4.41 | 1.01E−05 | 3.29E−02 | 0.11 | 0.08 | 1.38 | 1.68E−01 | 1 |
HSPA7 | 867.94 | −0.28 | 0.07 | −4.21 | 2.54E−05 | 3.94E−02 | −0.26 | 0.06 | −4.09 | 4.38E−05 | 0.12 |
SVEP1 | 715.2 | 0.38 | 0.09 | 4.24 | 2.27E−05 | 3.94E−02 | 0.29 | 0.09 | 3.27 | 1.08E−03 | 0.71 |
MT1X | 5020.4 | 0.37 | 0.09 | 4.2 | 2.64E−05 | 3.94E−02 | 0.21 | 0.09 | 2.36 | 1.83E−02 | 1 |
S100A8 | 92.33 | 0.21 | 0.05 | 4.23 | 2.36E−05 | 3.94E−02 | 0.03 | 0.05 | 0.64 | 5.22E−01 | 1 |
NR4A2 | 1860.74 | −0.37 | 0.09 | −3.97 | 7.16E−05 | 9.80E−02 | −0.29 | 0.09 | −3.1 | 1.92E−03 | 0.89 |
RPPH1 | 1246.73 | −0.01 | 0.07 | −0.18 | 8.60E−01 | 1 | 0.48 | 0.06 | 7.39 | 1.51E−13 | 3.29E−09 |
SCARNA2 | 192.55 | −0.01 | 0.06 | −0.11 | 9.15E−01 | 1 | 0.35 | 0.06 | 6.12 | 9.48E−10 | 1.04E−05 |
CDR1 | 2177.67 | 0.02 | 0.08 | 0.23 | 8.20E−01 | 1 | 0.48 | 0.08 | 5.88 | 4.08E−09 | 2.97E−05 |
PAR5 | 333.34 | 0.08 | 0.09 | 0.89 | 3.73E−01 | 1 | 0.47 | 0.09 | 5.42 | 5.82E−08 | 3.18E−04 |
RMRP | 604.09 | −0.01 | 0.05 | −0.28 | 7.81E−01 | 1 | 0.23 | 0.05 | 5.12 | 2.98E−07 | 1.30E−03 |
MTRNR2L6 | 9.75 | 0.06 | 0.07 | 0.93 | 3.52E−01 | NA | 0.3 | 0.06 | 4.72 | 2.37E−06 | 8.63E−03 |
MUC16 | 10.41 | 0 | 0.04 | −0.1 | 9.24E−01 | NA | 0.17 | 0.04 | 4.18 | 2.96E−05 | 9.24E−02 |
Abbreviation: NA, not available.
Counts is the average number of normalized read counts per sample; log2FC is log2 transformed fold change; lfcSE is the standard error of the log2 transformed fold change; Wald is the test statistic for differential expression; P-value is the nominal P-value of differential expression; MTC P is the adjusted P-value after multiple testing correction. Bold values are those that are significant after multiple testing correction (MTC P).