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. 2016 Aug 9;17(10):1410–1421. doi: 10.15252/embr.201642198

Figure 1. HIF‐bound enhancers are in a poised state in normoxia.

Figure 1

  • A–N
    Averaged signals at promoter‐distal (> 10 kb) HIF‐binding sites and at the promoters of hypoxia‐regulated genes for comparison are shown for HIF‐1β ChIP‐seq (A, B), total RNA‐seq (C, D), DNase‐seq (E, F), H3K4me1 ChIP‐seq (G, H), H3K4me3 ChIP‐seq (I, J), H3K27ac ChIP‐seq (K, L), and RNApol2 ChIP‐seq (M, N). Median RPKM (reads per kilobase per million reads, scaled to background signal) from normoxic (red) and hypoxic (blue) MCF‐7 cells are plotted for ± 10‐kb flanking regions.