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. 2016 Aug 9;17(10):1410–1421. doi: 10.15252/embr.201642198

Figure EV3. Differential transcriptional activation activity of HIF1 and HIF2.

Figure EV3

Binding sites bound both by HIF1 and HIF2 were identified and classified by the distance from the binding site to the closest TSS. Expression of the closest gene (normalized to the control siRNA) is shown for MCF‐7 cells treated with control siRNA, HIF1α siRNA, HIF2α siRNA or HIF1α and HIF2α siRNA combined. Genes were ordered by row according to hierarchical clustering.
  1. Genes bound by HIF at their promoters (2 kb or less).
  2. Genes bound by HIF at distal enhancers (10 kb or more).