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. 2016 Sep 14;17(10):1374–1395. doi: 10.15252/embr.201642195

Figure 3. Schematic ATF4 protein structure.

Figure 3

ATF4 protein consists of 351 amino acids organized into several domains and motifs. It contains basic domain for DNA binding and leucine zipper domain involved in protein–protein interactions. ATF4 has an oxygen‐dependent degradation domain, which is recognized by PHD3. ATF4 has β‐TrCP recognition motif, which is a degradation motif. Depending on the phosphorylation events mainly at S219, ATF4 is recognized by β‐TrCP and targeted for proteasomal degradation.