Table 1.

ATF4 interacting partners

Interacting partner	Name	Function	References
β‐TrCP	F‐box protein β‐transducin repeat‐containing protein	Interaction of β‐TrCP with ATF4 controls ATF4 stability and inhibits its transcriptional activity	153
CENP‐F	Centromere protein F	Interacts with ATF4 and negatively regulates ATF4 transcriptional activation in interphase	256
CEP290	Centrosomal protein of 290 kDa	Interacts with ATF4 and induces its transcriptional activity	257
CHOP	C/EBP homologous protein	Interaction between ATF4 and CHOP results in negative regulation of ATF4‐dependent transcriptional activation of the ASNS gene ATF4 and CHOP interact to induce target genes involved in protein synthesis and the UPR	122 258
PHD3	Prolyl hydroxylase 3	Regulates ATF4 protein stability	134
FAM175B (Abro1)	BRISC complex subunit Abro1	Interaction with ATF4 is crucial for the cytoprotective function of Abro1 in response to oxidative stress	259
FIAT	Factor inhibiting ATF4‐mediated transcription	Modifies early osteoblast activity by interacting with ATF4	260
FOS	Proto‐oncogene c‐Fos	Forms heterodimers with ATF4	261
Fra1	Fos‐related antigen 1	Forms heterodimers with ATF4	261
GABA(B)	Gamma‐aminobutyric acid type B	Interacts with ATF4 in mouse brain during the postnatal development	262
GPE‐1	GPE1‐binding protein	Forms heterodimers with ATF4 that regulate G‐CSF gene expression	263
HIF1A	Hypoxia inducible factor 1‐alpha	Interaction with ATF4 initiates bone angiogenesis in hypoxic osteoblasts	264
Jun	Proto‐oncogene c‐Jun	Forms heterodimers with ATF4	261
NIPK	Neuronal cell death‐inducible putative kinase (TRIB3)	Interacts with ATF4 and inhibits ATF4 transcriptional activity	265
Nrf‐2	Nuclear factor erythroid 2‐related factor 2	Interaction between ATF4 and Nrf2 regulates the expression of heme oxygenase‐1 gene	266
p300	Histone acetyltransferase p300	Interaction with p300 stabilizes ATF4 and increases its transcriptional activity	164
RPB3	RNA polymerase II subunit 3	Interaction with RPB3 enhances ATF4 transcriptional potential in muscle differentiation	267
RSK2 (RPS6KA3)	Ribosomal protein S6 kinase alpha‐2	ATF4 and RSK2 interact to regulate osteoblast differentiation and function	107
RUNX2	Runt‐related transcription factor 2	Interaction with ATF4 stimulates osteoblast differentiation and bone formation	268
SATB2	DNA‐binding protein SATB2	Regulates skeletal development and osteoblast differentiation through the direct interaction with ATF4 and enhances its activity	269
SKIP3	Orthologue of the Drosophila TRIB3 and rat NIPK	Interaction between SKIP3 and ATF4 is associated with ATF4 proteolysis	161
Tax of HTLV‐1	Trans‐activating transcriptional regulatory protein of HTLV‐1	ATF4 interacts with Tax and triggers Tax transactivation of HTLV	270
TRIB3	Tribbles homolog 3	Interacts with ATF4 and negatively regulates the ATF4‐dependent transcription.	135 197
Zhangfei	HCF‐binding transcription factor Zhangfei	Forms heterodimers with ATF4 and enhances its transcriptional activity	271
ZIP	Zipper‐interacting protein kinase	Forms heterodimers with ATF4, which inhibits the apoptotic activities mediated by ZIP	160