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ATF4 post‐translational modifications and their role
| Modification | Residue | Function | References |
|---|---|---|---|
| Acetylation | K311 | Inhibition of ATF4 ubiquitination | 164 |
| Hydroxylation |
P60 P235 |
Possible decrease in ATF4 transcriptional activity | 162 |
| Phosphorylation |
S219 S224 |
bTrCP‐dependent degradation | 153 272 |
|
S245 S251 S254 |
Upregulation of ATF4 transcriptional activity | 107 159 | |
| S215 | ATF4 stabilization | 273 | |
| Ubiquitination |
S219 D218 |
ATF4 degradation | 153 |
