Table 1. Top-15 most up-and down-regulated bovine proteins at 36 hours after intramammary challenge with Streptococcus uberis .

Up/down-regulated	UniProt ID	Protein name	Fold change	P-Value a
Up	Q8SPP7	Peptidoglycan recognition protein 1	3305	4.5 × 10–10
Up	P54229	Cathelicidin-5	1444	1.9 × 10–8
Up	P56425	Cathelicidin-7	1217	1.6 × 10–6
Up	P22226	Cathelicidin-1	1026	2.8 × 10–8
Up	Q2TBU0	Haptoglobin	997	3.8 × 10–8
Up	F1N465	Uncharacterized protein GN = KBTBD8	527	1.5 × 10–3
Up	E1BCU6	Uncharacterized protein GN = TCN1	401	1.5 × 10–6
Up	Q9TU03	Rho GDP-dissociation inhibitor 2	313	1.6 × 10–4
Up	P52176	Matrix metalloproteinase-9	219	1.1 × 10–4
Up	P33046	Cathelicidin-4	208	2.7 × 10–4
Up	Q0VCG9	Pentraxin-related protein PTX3	194	1.5 × 10–8
Up	Q58CQ9	Pantetheinase	189	8.5 × 10–4
Up	G3MXK8	Uncharacterized protein (Fragment) GN = PRTN3	167	1.2 × 10–3
Up	Q28085	Complement factor H	134	1.6 × 10–3
Up	Q3SZV7	Hemopexin	131	4.9 × 10–6
Down	P81265	Polymeric immunoglobulin receptor	–6	2.0 × 10–4
Down	Q3MHX6	Protein OS-9	–6	4.9 × 10–3
Down	P10790	Fatty acid-binding protein, heart	–7	3.2 × 10–4
Down	Q8WML4	Mucin-1	–38	2.7 × 10–3
Down	P13696	Phosphatidylethanolamine-binding protein 1	–39	1.8 × 10–3
Down	Q9XSG3	Isocitrate dehydrogenase [NADP] cytoplasmic	–50	5.0 × 10–5
Down	Q9TUM6	Perilipin-2	–61	2.0 × 10–3
Down	E1BLC6	Uncharacterized protein GN = TTC17	–67	4.3 × 10–3
Down	F1N1D2	Uncharacterized protein GN = DMC1	–77	4.6 × 10–3
Down	O18738	Dystroglycan	–77	1.2 × 10–3
Down	P26201	Platelet glycoprotein 4	–87	1.0 × 10–4
Down	E1B9W6	Uncharacterized protein GN = ADCY10	–145	2.5 × 10–3
Down	F6PZ29	Uncharacterized protein GN = MCFD2	–191	3.1 × 10–3
Down	F6QEL0	Cystatin-B	–204	1.8 × 10–4
Down	E1BN90	Uncharacterized protein GN = ZKSCAN2	–214	4.6 × 10–3

^aFalse discovery rate adjusted.