Table 2. Top-15 most up- or down-regulated bovine proteins at 42 hours after intramammary challenge with Streptococcus uberis .

Up/down-regulated	UniProt ID	Protein name	Fold change	P-value a
Up	P54229	Cathelicidin-5	9209	1.5 × 10–10
Up	P56425	Cathelicidin-7	8922	1.7 × 10–8
Up	Q8SPP7	Peptidoglycan recognition protein 1	8453	3.7 × 10–11
Up	Q2TBU0	Haptoglobin	4794	5.2 × 10–10
Up	P22226	Cathelicidin-1	3812	7.6 × 10–10
Up	P33046	Cathelicidin-4	2619	1.1 × 10–6
Up	E1BCU6	Uncharacterized protein GN = TCN1	1292	6.1 × 10–8
Up	P19660	Cathelicidin-2	1159	3.9 × 10–5
Up	F1MCC8	Uncharacterized protein GN = NWD1	1144	5.3 × 10–4
Up	Q0VCG9	Pentraxin-related protein PTX3	963	4.7 × 10–11
Up	F1N465	Uncharacterized protein GN = KBTBD8	961	6.0 × 10–4
Up	F1MKS5	Histidine-rich glycoprotein	775	6.3 × 10–6
Up	P52176	Matrix metalloproteinase-9	708	7.1 × 10–6
Up	F1N1F8	Uncharacterized protein GN = CENPF	661	5.7 × 10–3
Up	Q9TU03	Rho GDP-dissociation inhibitor 2	614	3.8 × 10–5
Down	P80457	Xanthine dehydrogenase/oxidase	–15	1.1 × 10–2
Down	P02702	Folate receptor alpha	–35	5.6 × 10–3
Down	P29392	Spermadhesin-1	–42	8.1 × 10–3
Down	Q8WML4	Mucin-1	–44	1.8 × 10–3
Down	P08037	Beta-1,4-galactosyltransferase 1	–51	1.9 × 10–3
Down	F1MNS0	Uncharacterized protein GN = HERC1	–58	2.6 × 10–3
Down	P63048	Ubiquitin-60S ribosomal protein L40	–70	3.2 × 10–3
Down	Q0VCX2	78 kDa glucose-regulated protein	–73	2.1 × 10–3
Down	F1N1D2	Uncharacterized protein GN = DMC1	–77	4.6 × 10–3
Down	O18738	Dystroglycan	–78	1.2 × 10–3
Down	P13696	Phosphatidylethanolamine-binding protein 1	–87	2.3 × 10–4
Down	P26201	Platelet glycoprotein 4	–87	1.0 × 10–4
Down	F6QEL0	Cystatin-B	–97	9.3 × 10–4
Down	F6PZ29	Uncharacterized protein GN = MCFD2	–201	2.8 × 10–3
Down	E1BN90	Uncharacterized protein GN = ZKSCAN2	–230	4.1 × 10–3

^aFalse discovery rate adjusted.