Table 4. Top-15 most up-and down-regulated bovine proteins at 81 hours after intramammary challenge with Streptococcus uberis .

Up/down-regulated	UniProt ID	Protein name	Fold change	P-value a
Up	Q2TBU0	Haptoglobin	28 858	6.1 × 10–12
Up	Q8SPP7	Peptidoglycan recognition protein 1	17 090	6.3 × 10–12
Up	P54229	Cathelicidin-5	11 722	8.0 × 10–11
Up	Q9TU03	Rho GDP-dissociation inhibitor 2	7794	1.8 × 10–7
Up	P48616	Vimentin	7549	2.2 × 10–12
Up	P56425	Cathelicidin-7	7316	2.6 × 10–8
Up	F1MYX5	Uncharacterized protein GN = LCP1	5417	7.3 × 10–8
Up	A6QLL8	Fructose-bisphosphate aldolase GN = ALDOA	4918	8.9 × 10–10
Up	E1BLI9	Protein S100-A9	4847	7.6 × 10–13
Up	P22226	Cathelicidin-1	4743	4.3 × 10–10
Up	Q5E9F7	Cofilin-1	4636	8.6 × 10–8
Up	Q9XSJ4	Alpha-enolase	4619	3.9 × 10–11
Up	Q3ZBD7	Glucose-6-phosphate isomerase	4533	5.7 × 10–8
Up	Q3ZCJ8	Dipeptidyl peptidase 1	3839	3.1 × 10–6
Up	P02584	Profilin-1	3799	3.7 × 10–7
Down	Q8WML4	Mucin-1	–102	2.3 × 10–4
Down	F1MIR2	Uncharacterized protein GN = EXOC6B	–119	7.5 × 10–4
Down	A8YXY3	15 kDa selenoprotein GN = SEP15	–123	1.4 × 10–3
Down	Q9TUM6	Perilipin-2 GN = PLIN2	–166	2.2 × 10–4
Down	E1BN90	Uncharacterized protein GN = ZKSCAN2	–221	4.3 × 10–3
Down	P29392	Spermadhesin-1	–327	1.3 × 10–4
Down	E1BGZ9	PHD finger protein 20-like protein 1	–337	2.8 × 10–3
Down	F1MMF2	Uncharacterized protein (Fragment)	–359	4.1 × 10–3
Down	Q3ZC66	Cysteine-rich PDZ-binding protein	–475	1.9 × 10–2
Down	F6PZ29	Uncharacterized protein GN = MCFD2	–799	2.9 × 10–4
Down	Q58DJ3	KIAA1984 OS = Bos taurus	–824	2.1 × 10–3
Down	E1B9W6	Uncharacterized protein GN = ADCY10	–2764	1.2 × 10–5
Down	Q8SQ24	Myozenin-1	–3030	7.2 × 10–4
Down	F1MV51	Uncharacterized protein GN = APC	–3282	2.5 × 10–4
Down	P00711	Alpha-lactalbumin	–7360	5.8 × 10–8

^aFalse discovery rate adjusted.