Figure 5. Potential relationship reflected by fungal secretome between hypovirulence and virus infection.

The fungal secretome consisted by intracellular components which secreted followed cell leakage, and extracellular components regulated by secretory pathway. After virus infection, intracellular components and secretory pathway were both regulated. This situation was shown by secretome changing tendency and further indicated that the aspects of nutrition acquisition, infective ability, energy metabolism and cell aging and death of this pathogenic fungus were regulated by virus infection which synthetically led to the phenomenon of hypovirulence.