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. Author manuscript; available in PMC: 2016 Oct 4.
Published in final edited form as: JAMA Psychiatry. 2016 May 1;73(5):515–524. doi: 10.1001/jamapsychiatry.2015.3463

Figure 3.

Figure 3

Reduced medial temporal volume in PS youth relative to TD youth develops in early adolescence. Voxelwise examination of nonlinear group-by-age interactions reveals significant differences in the developmental pattern of bilateral medial temporal lobes. Whereas ICV-adjusted medial temporal volumes are stable in TD youth, PS youth lose medial temporal volumes in late childhood and early adolescence, resulting in lower MTL volumes bilaterally by mid-adolescence. Image thresholded at z>2.3, corrected p<0.01; minimum cluster size: k>255 voxels. See eTable 2 for further details. Shaded regions represent 95% confidence intervals.