Table 4.
Association of gene score with CHD risk factors in NPSHII
| Trait | Tertile 1 (n = 454) | Tertile 2 (n = 455) | Tertile 3 (n = 451) | p value |
|---|---|---|---|---|
| Age (years) | 56.45 (3.43) | 56.17 (3.57) | 56.51 (3.57) | 0.86 |
| Total cholesterol (mmol/l) | 5.81 (0.98) | 5.73 (1.02) | 5.82 (0.98) | 0.17 |
| LDL-cholesterol (mmol/l) | 3.10 (1.03) | 3.18 (1.00) | 3.24 (0.94) | 0.05 |
| HDL-cholesterol (mmol/l) | 1.69 (0.58) | 1.65 (0.58) | 1.64 (0.59) | 0.23 |
| Triglyceride (mmol/l)a | 1.77 (0.92) | 1.82 (0.98) | 1.86 (0.99) | 0.19 |
| Systolic blood pressure (mmHg) | 139.88 (19.68) | 138.61 (18.98) | 139.66 (20.03) | 0.86 |
| Smoking % (n) | 28 % (n = 128) | 26 % (n = 119) | 31 % (n = 140) | 0.34 |
| Family history of CHD % (n) | 33 % (n = 139) | 34 % (n = 145) | 40 % (n = 169) | 0.03 |
| T2D onset % (n) | 2 % (n = 8) | 4 % (n = 17) | 3 % (n = 12) | 0.41 |
| BMI (kg/m2)a | 26.28 (3.20) | 26.23 (3.37) | 26.37 (3.48) | 0.68 |
Gene score was divided into tertiles. Linear regression was performed for the numeric variables and logistic regression was performed for the categorical variables. Mean value and standard deviation for each tertile is shown except for log transformed variables were the geometric mean and approximate standard deviation are shown
HDL high density lipoprotein, T2D type 2 diabetes, CHD coronary heart disease, BMI body mass index
aVariable was log transformed