Figure 1.

Concomitant exposure to HG and antiretroviral drug combination synergistically increases BBB endothelial toxicity. hCMEC/D3 cells were exposed to AZT (5μM) or/and IND (6μM) in NG or HG media for 24-72h and cell viability was determined by ATP luminescence (see Methods). Data were expressed as mean ± SEM (% control). **p<0.01 vs. control and #p<0.05 vs. AZT+IND or HG. The corresponding treatment conditions were shown below for each bar graph. N=5-6 biological replicates.