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. Author manuscript; available in PMC: 2017 Oct 21.
Published in final edited form as: Analyst. 2016 Aug 3;141(20):5714–5721. doi: 10.1039/c6an01055e

Figure 5.

Figure 5

3D-printed templates were used for microfluidic interfacing of two types of endocrine tissue for stimulation and temporal sampling. A) The insulin secretion rate from primary murine islets was clearly increased (p<0.05 for all points) in the presence of higher glucose levels, and the expected initial spike of insulin was observed. Five groups of <10 islets were assayed at high glucose, and two groups were assayed at low glucose (total of 7 microdevices used). B) Buoyant eWAT explants (2 mm) were trapped with 3D-printed accessories and interfaced to a 3D-templated device. After 30 min of treatment in HGHI solution, the explants were switched to LHLI solution, and the glycerol secretion rate was observed to increase, as expected. Three eWAT explants were evaluated on three separate microdevices.