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. Author manuscript; available in PMC: 2017 Dec 5.
Published in final edited form as: Mol Cell Endocrinol. 2016 Aug 6;437:35–50. doi: 10.1016/j.mce.2016.08.008

Figure 3. Diet-induced obesity disrupts KNDy-associated gene expression in the ARC (Experiment #2).

Figure 3

(A) Total lean mass percentage. (B) Total fat mass percentage. (C) Cumulative body weight gain. (D) Feeding efficiency. (E) Weekly energy intake (kCal). (F) KNDy genes: Kiss1, Tac2, and Pdyn; (G) KNDy-associated receptors: Kiss1r, Tac3r, and Kor; and (H) Steroid hormone receptors: Esr1 and Pgr. Gene expression data were normalized to ND-oil controls. (I) Plasma LH and (J) FSH levels. For all data, n = 8 – 10. (A–B, D–J) data were analyzed using a two-way ANOVA. (C) Data were analyzed by a repeated-measures, multifactorial ANOVA. All post hoc comparisons were Newman-Keuls multiple comparison tests. For (A–B), (D–J), a = p < 0.05; b = p < 0.01; c = p < 0.001; d = p < 0.0001). For (C), lowercase letters denote differences between steroid, within diet and uppercase letters denote differences between diet, within steroid (a/A = p < 0.05; b/B = p < 0.01; c/C= p < 0.001; d/D = p < 0.0001).