Table 3.

Associations between interleukin-6 (IL-6), matrix metalloproteinase-1 (MMP-1), MMP-3 and leptin in synovial fluid and suppressor of cytokine signaling-3 (SOCS-3) expression in cartilage from non-obese and obese patients with osteoarthritis

		Non-obese, BMI <30 kg/m2		Obese, BMI >30 kg/m2
Dependent variable	Covariates	R 2 adjusted	P	R 2 adjusted	P
LN (SF MMP-1)		0.15		0.30
	LN SOCS-3		0.818		0.007
	LN (SF leptin)		0.884		0.023
LN (SF MMP-3)		0.03		0.27
	LN SOCS-3		0.608		0.004
	LN (SF leptin)		0.733		0.015
LN (SF IL-6)		−0.05		0.20
	LN SOCS-3		0.945		0.003
	LN (SF leptin)		0.808		0.466

P values are calculated for covariates in analysis of variance modeling. The model is controlled for intergel variation in SOCS-3 expression levels. Analysis was performed in body mass index (BMI) subgroups. Natural logarithms (LN) were formed where appropriate. SF synovial fluid