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Potencies (μM, mean ± SEM) of lesinurad, benzbromarone, and probenecid against the resorptive uric acid transporters URAT1, OAT4, and GLUT9
| Reabsorptive uric acid transporter | |||
|---|---|---|---|
| Compound | URAT1 | OAT4 | GLUT9 |
| Lesinurad | 3.53 ± 0.52 | 2.03 ± 0.66 | >100 |
| Benzbromarone | 0.29 ± 0.06 | 3.19 ± 1.04 | ~100 |
| Probenecid | 13.23 ± 0.44 | 15.54 ± 3.39 | ND |
Results are from three experimentsfree concentration
