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. Author manuscript; available in PMC: 2016 Oct 4.
Published in final edited form as: Nat Rev Microbiol. 2016 Mar;14(3):135–149. doi: 10.1038/nrmicro.2015.24

Figure 5.

Figure 5

Advanced regulation relevant to NP biosynthesis. Examples include (a) inducible promoters for NP producing organisms216,217, (b) a mammalian genetic circuit responsive to a bacterial metabolite218, (c) dynamic modeling results for a synthetic pathway for para-aminostyrene production155, (d) a dynamic feedback/feedforward circuit for monitoring fatty acid ethyl ester production in E. coli54, (e) a resource allocation system for controlling transcription of a heterologous neurosporene operon in different hosts156, (f) a genetic reset timer for controlled sedimentation in yeast160, and (g) multiplexed transcriptional control of the violacein biosynthetic pathway using CRISPRi/CRISPRa172. For dynamic modeling example (c), graphs show frequencies of expected yields for designs with static regulation (top), dynamic regulation (middle), or for the particular pattern of dynamic regulation pictured at left (bottom).