Figure 3.

Increased efficacy of tumor growth suppression by CEA-specific CAR-T cells in preconditioned mice is associated with severe weight loss and eventual death of CEA-Tg mice, but not WT mice. (A) Body weight changes of CEA-Tg and WT mice from Fig. 2 were analyzed at the indicated time points (n = 5). (B) CAR-T cells prepared from CEA-Tg and WT mice and those mock-transduced T cells from WT mice were transferred into MC32a tumor-bearing CEA-Tg mice that also received fludarabine, cyclophosphamide, and total body irradiation. Body weight changes of CEA-Tg were analyzed at indicated time points. *p < 0.05, **p < 0.01.