| P-glycoprotein (P-9P) |
ABCB1 (MDR1) |
Luminal (Ref. 79) |
Yes (Refs 124-126) |
Vincristine, vinblastine, paclitaxel, docitaxel, doxorubicin, daunorubicin, mitoxantrone, etoposide, teniposide, methotrexate, topotecan, imatinib, dasatinib, lapatinib, gefitinib, sorafenib, erlotinib, tandutinib, |
| Breast Cancer Resistance Protein (BCRP) |
ABCG2 (MXR) |
Luminal (Ref. 101) |
Yes (Refs 131-133) |
doxorubicin, daunorubicin, mitoxantrone, methotrexate, topotecan, SN-38 (active metabolite of irinotecan), gimatecan, imatinib, dasatinib, lapatinib, gefitinib, sorafenib, erlotinib, tandutinib, |
| Multi-Drug Resistance Associated Protein 1 (MRP1) |
ABCC1 (MRP1) |
Luminal, Apical (Refs 87, 88) |
Yes (Refs 127,128,136) |
Etoposide, teniposide, vincristine, vinblastine, paclitaxel, docitaxel, doxorubicin, daunorubicin, mitoxantrone, topotecan, irinotecan, methotrexate |
| Multi-Drug Resistance Associated Protein 2 (MRP2) |
ABCC2 (MRP2) |
Luminal (Ref. 89) |
? |
Cisplatin, etoposide, vincristine, vinblastine, doxorubicin, daunorubicin, topotecan, irinotecan, methotrexate, paclitaxel, docitaxel |
| Multi-Drug Resistance Associated Protein 3 (MRP3) |
ABCC3 (MRP3) |
? |
Yes (Refs 128,136, 138) |
Etoposide, teniposide, vincristine, methotrexate |
| Multi-Drug Resistance Associated Protein 4 (MRP4) |
ABCC4 (MRP4) |
Luminal, Apical (Refs 87, 88) |
Yes (Refs 128,135) |
Methotrexate, topotecan, 6-mercaptopurine, thioguanine, cisplatin |
| Multi-Drug Resistance Associated Protein 5 (MRP5) |
ABCC5 (MRP5) |
Luminal, Apical (Refs 87, 88) |
Yes (Refs 128, 135, 136) |
6-mercaptopurine, thioguanine, gemcitabine |
