Table 1.
Descriptive characteristics of cohort 1 (original) and cohort 2 (new)
| Characteristics | Combined cohorts | Individual cohorts | p valuea | |
|---|---|---|---|---|
| Cohorts 1 and 2 (n=140) no (%) median |
1 (n=78) no (%) median | 2 (n=62) no (%) median | ||
| Median age in years at diagnosis (range in years) | 59.50 (37–82) | 62 (37–81) | 59 (38–82) | 0.15 |
| Follow-up time in months (range in months) | 35 (1–85) | 54 (1–85) | 26 (5–54) | <0.01 |
| Gender, male/female | 107 (76)/33 (24) | 56 (72)/22 (28) | 51 (82)/11 (18) | 0.15 |
| Lymph node stage treated (n=129) | ||||
| N0/N+ | 37 (29)/92 (71) | 25 (32)/53 (68) | 12(24)/39(76) | 0.30 |
| Primary tumor stage (n=135) | ||||
| 1 or 2 / 3 or 4 | 69 (51)/66 (49) | 38 (49)/40 (51) | 31(54)/26(46) | 0.52 |
| Disease site condensed (n=134) | ||||
| Oral cavity | 4 (3) | 4 (5) | 0 (0) | |
| Oropharynx | 79 (59) | 42 (54) | 37 (66) | |
| Hypopharynx | 9 (7) | 4 (5) | 5 (9) | |
| Larynx | 42 (31) | 28 (36) | 14 (25) | 0.13 |
| Median RT duration in days | 50 (38–83) | 51 (39–83) | 46 (38–67) | <0.01 |
| Median pretreatment Hgb (g/dl) (range) | 13.80 (8.60–19.40) | 13.50 (9–17.10) | 14 (8.60–19.40) | 0.17 |
| Median pretreatment weight (kg) (range) | 80.05 (42.60–141) | 79.75 (46.80–141) | 81.75 (42.60–125.50) | 0.39 |
| Median pretreatment IBW % (range) | 116 (72–193) | 113.5 (73–193) | 120 (72–190) | 0.24 |
| Pretreatment weight status by IBW% | ||||
| <90 % IBW | 20 (14) | 14 (18) | 6 (10) | |
| ≥90 % IBW | 120 (86) | 64 (82) | 56 (90) | 0.23 |
| Median pretreatment BMI (range) | 26.53 (16.58–45.10) | 25.89 (16.58–45.10) | 27.37 (16.90–41.55) | 0.24 |
| Pretreatment weight status by BMI | ||||
| ≤20 BMI | 12 (8.6) | 8 (10.3) | 4 (6.5) | |
| >20 BMI | 128 (91.4) | 70 (89.7) | 58 (93.5) | 0.43 |
| Median weight loss during RT (kg) (range) | 6.90 (−5–26) | 6.50 (−5–26) | 7 (−2.90–20.10) | 0.86 |
| Median weight loss % during RT (range) | 8.56 (−5.95–24.07) | 9.08 (−5.95–24.07) | 8.30 (−5.58–20.30) | 0.35 |
| Loco-regional progression: no/yes | 122 (87)/18 (13) | 63 (81)/15 (19) | 59 (95)/3 (5) | 0.01 |
RT radiation therapy, Hgb hemoglobin, g/dl grams per deciliter, kg kilogram, IBW ideal body weight
a
p value is for comparison between cohort 1 and 2; Chi square (two-tailed) was used to examine differences for categorical variables and Mann–Whitney U (two-tailed) was used to examine differences for continuous variables; statistical analysis compares cohort 1 to cohort 1