Table 2.
Topological Properties of Gyrification-Based Connectome
| Controls | Responders | Nonresponders | FDA Permutation Test (P values) | |
|---|---|---|---|---|
| Small-world index | 1.86 (0.64) | 1.78 (0.52) | 1.26 (0.19) | Con vs Res |
| *Con > NonRes (.003) | ||||
| *Res > NonRes (.02) | ||||
| Measures of segregation | ||||
| Clustering coefficient | 0.5143 (0.05) | 0.5240 (0.07) | 0.6052 (0.08) | Con vs Res (.73) |
| *Con vs NonRes (.01) | ||||
| *Res vs NonRes (.005) | ||||
| Local efficiency | 0.7234 (0.07) | 0.7278 (0.08) | 0.7629 (0.09) | Con vs Res (.71) |
| *Con < NonRes (.04) | ||||
| Res < NonRes (.06) | ||||
| Measures of integration | ||||
| Characteristic path length | 1.9418 (0.53) | 1.9341 (0.52) | 2.0946 (0.67) | Con vs Res (.59) |
| *Con < NonRes (.04) | ||||
| Res < NonRes (.10) | ||||
| Global efficiency | 0.609 (0.11) | 0.612 (0.11) | 0.592 (0.13) | Con vs Res (.50) |
| Con > NonRes (.09) | ||||
| *Res > NonRes (.04) | ||||
| Measures of resilience | ||||
| Assortativity | 0.185 (0.12) | 0.286 (0.07) | 0.273 (0.13) | *Con < Res (.03) |
| Con vs NonRes (.62) | ||||
| Res vs NonRes (.63) | ||||
| Relative size of large component after targeted attack | 42.2% (34%) | 40.7% (34%) | 30.2% (33%) | Con vs Res (.30) |
| *Con > NonRes (.04) | ||||
| *Res > NonRes (.01) | ||||
| Relative size of large component after random attack | 43.5% (33%) | 43.5% (32%) | 39.7% (30%) | Con vs Res (.50) |
| *Con > NonRes (.04) | ||||
| Res vs NonRes (.15) | ||||
| Modularity coefficient | 0.354 (0.13) | 0.334 (0.10) | 0.253 (0.10) | Con vs Res (.47) |
| *Con > NonRes (.03) | ||||
| *Res vs NonRes (.03) | ||||
| Hubs based on degree centrality | ||||
| Regions with degree 2 SDs greater than group mean | Right posterior cingulate | None | Right rostral middle frontal Right supramarginal | |
Note: FDA, Functional Data Analysis; Con, Controls; Res, Responders; NonRes, Nonresponders. Direction of change shown only for significant results that reach at least a trend level statistical threshold (P = .1). Numbers in brackets refer to SDs across the different densities at which comparison were made.
*P < .05 in FDA permutation analysis.