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. 2016 Sep 26;26(18):2486–2491. doi: 10.1016/j.cub.2016.07.013

Figure 3.

Figure 3

Impact of Natural OH Cell Activity on Rebound Eating after Fasting

(A) Eating responses to a 1-day fast in control mice (OH+, DTR− mice injected with DT) and their OH cell-deficient littermates (OH−, DTR+ mice injected with DT). n = 6 mice in each group.

(B) Daily eating rhythms before and after a 1-day fast in OH+ and OH− littermates. n = 6 mice in each group.

(C) Daily eating rhythms 3 days before and after food restriction. Repeated-measures ANOVA, interaction: F(7, 35) = 3.36, p = 0.008 (left) and F(7, 35) = 3.53, p = 0.006 (right). Follow-up tests showed significant differences only at times marked with asterisks (∗∗p < 0.01, ∗∗∗p < 0.001, Holm correction for multiple comparisons). n = 6 mice in each group.

(D) Total food consumed 3 days before (fed) and 3 days after (fast) food restriction in OH+ and OH− mice (n = 6 in each group) during early night (ZT12–14) compared to that consumed during late night (ZT18–20). Paired t tests.