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. 2015 Sep 1;237(4):482–494. doi: 10.1002/path.4594

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© 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PATH-4594-FIG-0001-c — Expression of Lmptp during embryonic and postnatal cardiac development and after pathological stress. (A) Immunoblot of Lmptp in adult mouse heart. (B) Indirect immunofluorescence of adult mouse heart sections showing Lmptp expression in the sarcolemmal membrane and lower expression in the cytosol. Signals were visualized by confocal microscopy using a 20× objective. (a) Lmptp expression; (b) negative control; (c) higher magnification of a; (d) higher magnification of b. (C) Immunoblot showing the developmental time course of Lmptp expression in mouse heart at embryonic days E11.5, E15, and E19, and at postnatal days 1 (P1) and 7 (P7) and at day 30. (D) Quantitation of C. (E) LMPTP protein level in control and failing human hearts measured by immunoblot and (F) quantitative analysis (n = 5). (G) Immunoblot of Lmptp in the hearts of wild‐type (WT) mice subjected to sham operation or TAC for 10 weeks (n = 4) and (H) quantitative analysis. p values are indicated (Student's t‐test).