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. 2015 Sep 1;237(4):482–494. doi: 10.1002/path.4594

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© 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PATH-4594-FIG-0004-c — Microarray analysis of Acp1^+/+ and Acp1^−/− mouse hearts after sham or TAC surgery. (A) Heat map showing the clustering of significantly dysregulated genes in Acp1^−/− and Acp1^+/+ mice after sham surgery (n = 2) or TAC (n = 5) (p < 0.01, 428 probes). Red colour indicates genes significantly up‐regulated, while green indicates genes significantly down‐regulated. (B) Major diseases and functions connected to genes dysregulated in Acp1^+/+ TAC hearts compared with Acp1^−/− TAC hearts. (C) Immunoblot of CaMKIIδ, Gαq/11, and PLC protein expression in Acp1^−/− TAC hearts compared with Acp1^+/+ TAC hearts. (D) Quantitative analysis of C over GAPDH control (n = 3–5). (E) Immunoblot of anti‐ and pro‐apoptotic proteins in Acp1^−/− TAC hearts compared with Acp^+/+ TAC hearts. (F) Quantitative analysis of E over GAPDH control (n = 3–5). Significant p values are shown (Student's t‐test).