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. 2015 Sep 1;237(4):482–494. doi: 10.1002/path.4594

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© 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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PATH-4594-FIG-0005-b — Increased IR phosphorylation, PKA, and ephrin receptor expression in Acp1^−/− hearts subjected to TAC compared with Acp1^+/+ TAC hearts. (A) Ingenuity pathway analysis showing the most significantly increased canonical pathways in Acp1^−/− TAC hearts compared with Acp1^+/+ TAC hearts after 10 weeks of TAC or sham surgery. (B) Immunoprecipitation from Acp1^+/+ and Acp1^−/− mouse hearts after 10 min and 24 h of sham or TAC using anti‐IRβ antibody followed by immunoblotting using anti‐4G10 antibody. (C) Quantitation of B; n = 3 in each group of mice. (D) Immunoblot for PKA, NFκB, and ephrin receptor in Acp1^+/+ and Acp1^−/− mouse hearts after 10 min and 24 h of sham or TAC. (E) Quantitation of D from three animals in each group. p values between Acp1^+/+ TAC and Acp1^−/− TAC hearts after Student's t‐test are shown.