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. 2015 Sep 10;135(4):814–829. doi: 10.1111/jnc.13273

Figure 8.

Figure 8

Schematic drawing of hypothetical neural circuit of habenular kisspeptin 1 (Kiss1) neurons. The lateral subnucleus of the dHb projects to the dIPN while the medial subnucleus of the dHb projects to the vIPN. Some cells in the vHb express glutamate (light blue dot). Both Kiss1 (purple dot) and Kiss‐R1 express in the vHb and project down (purple line) to the vaMR, a subregion of the MR [a division of the Superior raphe (SR)], through the fasciculus retroflexus (FR). The presynaptic action of the Kiss1/K‐R1 system causes the release of glutamate in co‐expressing cells (dark blue dot) from the vHb (dark blue line) that potentially regulates the 5‐HT system in the dMR directly or via glutamatergic (light blue line) and GABAergic neurotransmission (yellow line). Modified from Amo et al. (2010, 2014) and Lillesaar et al. (2007).