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. 2015 Sep 14;29(12):2390–2398. doi: 10.1111/jdv.13248

Table 1.

Key literature search findings, grouped by theme

Theme Key findings
Adherence Different biologics have different levels of adherence9
Better adherence is observed when the dermatologist clarifies the treatment schedule10
Better adherence is observed when the dermatologist keeps the patient informed and meets the patient's requests10
Decision making No biological can be considered best for all patients11
Patient preference should be a major deciding factor in biological choice11
The dermatologist is the most important source for patient understanding of biologics, followed by research on the internet12
The life course of patients has an impact on treatment strategies13, 14
Fear of adverse effects is an important factor in patient preference11, 15
Quality of life Treatment strategy has an impact on DLQI16
Patients on topical and traditional systemic therapies have higher DLQI scores16, 17
Patients with high DLQI and PASI scores benefit most from biologics18
Skindex‐29, a QoL scoring system, does not correlate with improvements in PASI19
DLQI is an independent predictor of work productivity20
Patient/physician goals Achieving PASI‐75 leads to improvement of the HRQoL index (lack of direct correlation of PASI with DLQI)21, 22
The Patient Benefit Index can be used as goal attainment scaling tool23
Questionnaires When addressing the patient, the physician should use simple language and improve the patient′s psychological skills24
It is important to communicate to the patient:24
(i) That the physician understands the disease
(ii) That there is hope of cure
(iii) The perception of control
Patient‐reported outcomes A clear definition of patient‐reported outcomes is needed
Biologics also have a benefit on non‐PASI outcomes3
Satisfaction Patients with high disease severity need a patient‐centred approach, as they are often dissatisfied with therapy25
A study of 1293 patients revealed that topical therapy was significantly associated with least satisfaction; highest satisfaction was seen with biologics5
For satisfaction, patients rated treatment effectiveness as most important, followed by treatment safety and doctor/patient communication5
Patient benefit index PBI is a suitable instrument for the assessment of the patient‐reported benefit8
More tools for understanding parameters of patient benefit and satisfaction are needed26

DLQI, dermatology quality of life index; HRQoL, health‐related quality of life; PASI, psoriasis area severity index.