Table 1.
Percentage of fascicle area per nerve, total fibres per nerve, fibre density in fascicles, fibre area in fascicles, percentage of large fibres per nerve, large fibre diameter, axon diameter and myelin width 14 days after intraneural (extrafascicular) and perineural injections of liposomal bupivacaine and intraneural (extrafascicular) injections of saline. Values are mean (SD)
| Type of injection | Percentage of fascicle area per nerve | Total number of fibres per nerve | Fibre density in fascicles; fibres.mm2 | Fibre area in fascicles; μm2 | Percentage of large fibres per nerve | Large fibre diameter; μm | Axon diameter; μm | Myelin width; μm |
|---|---|---|---|---|---|---|---|---|
| Intraneural liposomal bupivacaine | 47.5 (10.6) | 29817 (10838) | 15074 (7018) | 34.1 (16.2) | 50.8 (17.1) | 8.9 (2.1) | 3.7 (2.0) | 2.6 (0.5) |
| Perineural liposomal bupivacaine | 54.5 (8.3) | 34527 (14516) | 15015 (5572) | 24.1 (4.0) | 65.4 (19.1) | 8.3 (1.6) | 3.1 (0.3) | 2.6 (0.7) |
| Intraneural saline | 56.3 (7.6) | 33051 (20870) | 12254 (3008) | 29.1 (9.3) | 67.7 (15.7) | 9.0 (0.9) | 3.5 (0.6) | 2.7 (0.6) |
| Negative control (non‐injected) | 54.2 (3.7) | 37218 (20870) | 15212 (7267) | 30.2 (13.4) | 61.4 (21.9) | 8.8 (1.4) | 3.5 (1.0) | 2.6 (0.4) |
| p value | 0.059 | 0.843 | 0.214 | 0.100 | 0.450 | 0.905 | 0.844 | 0.990 |
There was no statistically significant difference among groups.