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. Author manuscript; available in PMC: 2016 Oct 11.
Published in final edited form as: Nat Chem Biol. 2016 Apr 11;12(6):419–424. doi: 10.1038/nchembio.2061

Figure 3. Model for fumisoquin biosynthesis.

Figure 3

(A = adenylation, T = thiolation, R = short-chain dehydrogenase/reductase domain, P: pyridoxal phosphate binding domain), [Red.] = reduction, [Ox.] = oxidation. The proposed mechanism for FsqB-mediated isoquinoline formation is based on functional similarity to plant BBE17–19, see Fig. 5 for details. The role of the ATP-grasp enzyme FsqD in activating tyrosine to form 19 is putative.