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. Author manuscript; available in PMC: 2016 Oct 11.
Published in final edited form as: Nat Chem Biol. 2016 Apr 11;12(6):419–424. doi: 10.1038/nchembio.2061

Figure 4. The fumisoquins incorporate L-serine, L-tyrosine, and an L-methionine-derived methyl group.

Figure 4

Shown are HPLC-MS ion chromatograms derived from fungal cultures grown with (a) L-serine or L-[13C3,15N]-serine, (b) L-tyrosine or L-[2-13C]-tyrosine and (c) L-methionine or L-[1′-13C]-methionine. In contrast, L-cysteine is not incorporated (Supplemental Fig. 6). See Supplementary Fig. 7 for mass spectra. (*) denotes labeled isotopes. In the case of L-[13C3,15N]-serine, loss of 15N due to partial deamination/amination contributes to increased m/z = 362.