Table 4.
Carriage of specific pneumococcal subtypes in children with cancer according to pneumococcal vaccination statusa
| Vaccinated with PCV7 (n = 58) | Not vaccinated against pneumococcus (n = 216) | OR (95% CI)b | |
|---|---|---|---|
| Carriers of PCV13 serotypes | 15 (25.9) | 26 (12.0) | 1.60 (0.68-3.73) |
| Number of PCV13 serotypes carried | |||
| 1 | 6 (10.3) | 13 (6.0) | 0.91 (0.28-2.97) |
| ≥2 | 9 (15.5) | 13 (6.0) | 2.30 (0.80-6.61) |
| Serotype carried | |||
| Positive for serotype 1 | 0 (0.0) | 1 (0.5) | NE |
| Positive for serotype 3 | 1 (1.7) | 1 (0.5) | 4.15 (0.09-183.0) |
| Positive for serotype 4 | 6 (10.3) | 6 (2.8) | 3.11 (0.77-12.49) |
| Positive for serotype 5 | 2 (3.4) | 2 (0.9) | 2.82 (0.30-26.92) |
| Positive for serotype 6A | 1 (1.7) | 0 (0.0) | NE |
| Positive for serotype 6B | 0 (0.0) | 1 (0.5) | NE |
| Positive for serotype 7F | 0 (0.0) | 1 (0.5) | NE |
| Positive for serotype 9V | 1 (1.7) | 4 (1.8) | 1.09 (0.09–13.68) |
| Positive for serotype 14 | 0 (0.0) | 0 (0.0) | NE |
| Positive for serotype 18C | 0 (0.0) | 0 (0.0) | NE |
| Positive for serotype 19A | 2 (3.4) | 0 (0.0) | NE |
| Positive for serotype 19F | 14 (24.1) | 25 (11.6) | 1.43 (0.60–3.40) |
| Positive for serotype 23F | 0 (0.0) | 1 (0.5) | NE |
| Carriers of non-PCV13 serotypes | 4 (6.9) | 7 (3.2) | 2.06 (0.52–8.09) |
a
Three subjects had missing information on pneumococcal vaccination.
b
ORs adjusted for age at enrollment, gender, siblings, parental smoking, disease phase, co-trimoxazole prophylaxis and diagnosis. For the analyses on single serotypes, the reference category is non-carrier of each corresponding serotype.
CI: confidence interval; NE: not estimable; OR: odds ratio; PCV7: 7-valent pneumococcal conjugate vaccine.