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. 2015 Sep 11;12(2):491–502. doi: 10.1080/21645515.2015.1082693

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Flowchart illustrating the study population and experimental design. The study was based on two branches: The humoral (A) and cellular (B) immunology analysis. The eligible population comprises 171 adults. Blood collections (without anticoagulant for humoral analysis and in heparinized tubes for cellular immunology assessment) were performed prior vaccination (NVday0 (n=39) and at different timepoints after primary vaccination: PVday30-45 (n=39); PVyear1-4 (n=36); PVyear5-9 (n=12); PVyear10-11 (n=45) and PVyear12-13 (n=39).