Fig 6. 5-Choice Serial Reaction Time Task (5-CSRTT) Results Longitudinally for Hdh^Q111/+ animals over 18 months of testing.

A. Total trials started. Animals initiated significantly fewer trials as the stimulus length was decreased, at all ages. Hdh^Q111/+ animals initiated significantly fewer trials than wild type animals, largely due to the magnitude of difference in the number of initiated trials at 18 months of age. B. Accuracy. Animals were significantly less accurate in responding at shorter stimulus lengths and were significantly more accurate is responding to the central hole in comparison to the peripheral holes. Hdh^Q111/+ animals were significantly less accurate than wild type animals, although no genotype by age interaction was demonstrated. C. Response time. Animals responded faster to the shorter stimulus lengths and into the central hole in comparison to peripheral holes. Hdh^Q111/+ animals were significantly slower to respond to the stimulus than wild type animals. D. Time out responses. Animals made significantly more time outs as stimulus length decreased. Animals also made significantly more time outs at the peripheral holes in comparison to the central hole. Data are shown for a total of 16 mice, 7 Hdh^Q111/+ and 9 wild type and is the average number of responses made over 5 days of testing at each stimulus length. Error bars represent ± standard error of the mean. * p<0.05, ** p<0.01, *** p<0.001.