Fig 8. Serial Reaction Time Task (SILT) Results for Accuracy and Response Time for predictability of stimulus in Hdh^Q111/+ animals longitudinally.

A. S2 Accuracy. Mice were significantly more accurate when the duration of the stimulus length was increased and when the stimulus was predictable rather than unpredictable Hdh^Q111/+ animals were significantly less accurate overall in responding in comparison to wild type animals The predictability of the stimulus did not confer any significant benefit to either wild type animals or Hdh^Q111/+ animals. B. S2 Response Time. The predictability of the S2 stimulus in the SILT did not confer any significant advantage to how rapidly animals were able to respond. Hdh^Q111/+ animals showed a trend to be significantly slower than wild type animals in all testing conditions, this trend failed to meet the threshold for statistical significance. Data are shown for a total of 16 mice, 7 Hdh^Q111/+ and 9 wild type and is the average number of responses made over the final 5 days of testing at each stimulus length. Error bars represent ± standard error of the mean. * p<0.05, ** p<0.01, *** p<0.001.