Table 2. Pharmacokinetics parameters of ACT-451840 in healthy mice (n = 4).
Pharmacokinetic parameters measured | |||
---|---|---|---|
Dose (mg/kg) | Tmax (h) | Cmax (ng/mL) | AUC (ng/mL*h) |
10 | 2.5 | 415 ± 20% | 1,780 ± 18% |
100 | 6 | 3,910 ± 20% | 32,900 ± 36% |
300 | 7 | 7,010 ± 32% | 60,900 ± 33% |
Abbreviations: time to reach the maximum observed plasma concentration (Tmax), maximum observed plasma concentration (Cmax), area under the concentration versus time curve (AUC).