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CHRNA5 rs16969968 predicts risk of lung cancer. Smoking cessation decreases probability of lung cancer regardless of CHRNA5 rs16969968 genotype.
Quit: individuals who report having quit smoking when ascertained as cases of lung cancer or controls.
N = 12,690 (6988 cases of lung cancer and 5702 controls).
All participants have smoked at least 100 cigarettes (5833 active smokers, 6857 smokers who have quit).
Adjusted for age, sex and rs16969968 genotype.
