TABLE 1.
Injectable (and Nasal) Generic | Intranasal Branded | Injectable Generic | Auto-injector Branded | |
FDA approval | X (for IV, IM, SC) | X | X | X |
Layperson experience | X | X | X | |
Fragile; requires assembly | X | X | ||
Can titrate dose | X | X | ||
Strength | 1 mg/mL | 4 mg/0.1 mL | 0.4 mg/mL or 4 mg/10 mL | 0.4 mg/0.4 mL |
Cost per kit | $$ | $$ | $ | $$$ |
Rx and quantity | #2, 2 mL Luer-Jet Luer-Lock needleless syringe plus #2 mucosal atomizer devices (MAD-300) | #1 two-pack of two 4-mg/0.1 mL intranasal devices | #2 single-use 1-mL vials or #1 10-mL multidose fliptop vial PLUS #2 3 mL syringe with 23 to 25 gauge 1–1.5 inch IM needles | #1 two-pack of two 0.4 mg/0.4 mL prefilled auto-injector devices |
Sig. (for suspected opioid overdose) | Spray 1 mL (1/2 of syringe) into each nostril. Repeat after 2 to 3 minutes if no or minimal response | Spray 0.1 mL into one nostril. Repeat with second device into other nostril after 2 to 3 minutes if no or minimal response | Inject 1 mL in shoulder or thigh. Repeat after 2 to 3 minutes if no or minimal response | Inject into outer thigh as directed by English voice-prompt system. Place black side firmly on outer thigh and depress and hold for 5 seconds. Repeat with second device in 2 to 3 minutes if no or minimal response |
Some portions developed with funding from NIDA R01 DA034634.